Description

About Ratio Therapeutics

Ratio Therapeutics is committed to improving and extending the lives of cancer patients without sacrificing their quality of life. We are a team of passionate scientists, engineers, and business professionals dedicated to advancing the field of targeted radioligand therapy. To accomplish this, we utilize our proprietary TRILLIUM™ and MACROPA™ platforms: TRILLIUM™ allows fine-tuning of radioligand pharmacokinetics thereby enhancing the therapeutic index, while MACROPA™ simplifies the manufacturing process for the alpha-emitting isotope, actinium-225. These enabling platform technologies have resulted in an emergent pipeline of novel therapeutic candidates. We are looking for talented, dedicated, and creative individuals eager to help us advance these technologies from discovery research through clinical development. Join us in our quest to become the leading innovator in radioligand therapy and improve the lives of cancer patients and their families.

About the Position

Ratio is seeking a Clinical Research Physician to join a growing team of scientists to oversee our increasing portfolio of clinical trials, provide medical monitoring and clinical development of new molecules. The successful candidate will be a physician with a core understanding of ICH GCP and clinical development and is looking to develop their skills and experience in this area. The role involves providing medical input the design, execution, and interpretation of the global clinical studies in Ratio’s development pipeline whilst prioritizing patient safety. Working closely with cross-functional internal and external teams especially clinical operations, regulatory affairs, quantitative sciences, and imaging/medical physics, the Clinical Research Physician will provide medical and scientific accountability to ensure the integrity and success of clinical programs. The ideal candidate will be highly collaborative with a quality and patient focus and have a good eye for detail, working in a fast-paced Biotech environment.

Key Responsibilities:

Clinical Development and Medical Monitoring

• Provide medical input into the design and conduct of clinical trials, especially early-stage development studies.
• Serve as the medical monitor for assigned clinical trials, ensuring patient safety, medical data quality, scientific integrity, and adherence to protocol and GCP standards.
• Lead or contribute to the development of key documents including clinical study protocols, investigator brochures, informed consent forms, study plans and manuals, and clinical study reports.

• Collaborate with clinical operations other Ratio functions, contract research organizations (CRO) and site investigators to operationalize clinical trials.

• Provide medical review of pharmacovigilance activities including SAE and AEs, periodic reports and signal detection.

• Interpret clinical data to inform dosage selection, patient population selection, imaging & biomarker strategies, and regulatory interactions. Integrate emerging clinical findings into overall development strategy.

• Participate or chair (as required) external meetings including study safety review committees, data safety monitoring boards and study steering committees.
• Support investigator meetings and site meetings (as required). Ensure appropriate medical training of investigators and study teams (internal, CRO, and clinical site teams).

• Stay abreast of scientific and competitive developments in relevant therapeutic areas.

Regulatory & External Engagement

• Support preparation of clinical sections of clinical trial regulatory documentation.
• Support engagement with regulatory agencies and ethics committees / institutional review boards as a clinical representative.
• Build and maintain relationships with key opinion leaders, academic collaborators, and clinical sites.
• Represent the company at scientific and medical conferences.

Qualifications:

• MD, MB BS or equivalent medical degree required; specialization and prior experience in pharmaceutical medicine, oncology and / or nuclear medicine / radiology / radiation oncology advantageous.
• Minimum of 1-3 years’ experience in clinical research within pharmaceutical or biotechnology industry, academia or clinic.
• Demonstrated understanding of clinical trial design, GCP, ICH, and regulatory requirements.
• Strong analytical skills, with a focus on data-driven decision making and adaptability.
• Excellent communication skills and highly collaborative approach to enable working across functions and organizations.
• Ability to work in a fast-paced, entrepreneurial, data-driven environment. Identify and utilize technology to enhance the quality of delivery of clinical development studies and programs.

• Ideally experience in oncology, nuclear medicine or radiopharmaceuticals.
• Experience with early phase clinical trials preferred.
• Commitment to patient safety, scientific rigor, and innovation.

Location and travel:

• Ideal candidate is based in UK.
• Occasional travel to Boston headquarters, clinical sites, investigator meetings, or scientific conferences.
• Flexible, fast-paced biotech setting with cross-disciplinary collaboration.
• Availability for urgent clinical or safety consultations during study periods.

The annual base salary for this role is expected to range between £80,000.00 and £99,000.00. This range is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. The actual base salary offered will depend on a variety of factors, including qualifications, work experience, skills, level of education attained, certifications or other professional licenses held, the location in which the applicant lives and/or from which they will be performing the job, and other job-related factors permitted by law.